Title
Investigation on the genotoxicity of extracts from **Cleome amblyocarpa** Barr. and Murb, an important Tunisian medicinal plant Investigation on the genotoxicity of extracts from **Cleome amblyocarpa** Barr. and Murb, an important Tunisian medicinal plant
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Capetown ,
Subject
Biology
Pharmacology. Therapy
Source (journal)
South African journal of botany. - Capetown
Volume/pages
84(2013) , p. 102-103
ISSN
0254-6299
ISI
000314261600014
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
We conducted an investigation of the in vitro toxic and genotoxic properties of Cleome amblyocarpa Barr. and Murb, which is an important medicinal plant in Tunisia where it is widely used against colic and diabetes. In this study we investigated methanol extracts of the whole plant with the neutral red uptake test for assessing its in vitro toxicity and the alkaline comet assay for genotoxicity. It appeared that the extract was not genotoxic in subtoxic concentrations. However, the neutral red uptake test revealed that it was highly toxic and therefore some caution, especially regarding dosage and frequency of use, is warranted.
E-info
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