Publication
Title
Biological evaluation of bisbenzaldehydes against four **Mycobacterium** species
Author
Abstract
A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant M. tb, against virulent M. bovis, against M. ulcerans and against two M. avium subspecies. Among the 33 substances that were tested, compound 12, i.e. 4,4-[1,12-dodecanediyl(oxy)]bisbenzaldehyde emerged as the most promising hit. Its activity was further confirmed in an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no genotoxicity or mutagenicity was observed, as demonstrated by a VITOTOXTM test and confirmed with a comet assay.
Language
English
Source (journal)
European journal of medicinal chemistry. - Paris, 1974, currens
Publication
Paris : 2013
ISSN
0223-5234
Volume/pages
63(2013), p. 731-738
ISI
000322855400072
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 28.03.2013
Last edited 11.07.2017
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