Publication
Title
Role of protein biomarkers in the detection of high-grade disease in cervical cancer screening programs
Author
Abstract
Since the Pap test was introduced in the 1940s, there has been an approximately 70% reduction in the incidence of squamous cell cervical cancers in many developed countries by the application of organized and opportunistic screening programs. The efficacy of the Pap test, however, is hampered by high interobserver variability and high false-negative and false-positive rates. The use of biomarkers has demonstrated the ability to overcome these issues, leading to improved positive predictive value of cervical screening results. In addition, the introduction of HPV primary screening programs will necessitate the use of a follow-up test with high specificity to triage the high number of HPV-positive tests. This paper will focus on protein biomarkers currently available for use in cervical cancer screening, which appear to improve the detection of women at greatest risk for developing cervical cancer, including Ki-67, p16 INK 4a, BD ProEx C, and Cytoactiv HPV L1.
Language
English
Source (journal)
Journal of oncology
Publication
2012
ISSN
1687-8450
Volume/pages
(2012), 11 p.
Article Reference
289315
Medium
E-only publicatie
Full text (Publishers DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Record
Identification
Creation 08.04.2013
Last edited 12.03.2017
To cite this reference