Title
Role of protein biomarkers in the detection of high-grade disease in cervical cancer screening programs Role of protein biomarkers in the detection of high-grade disease in cervical cancer screening programs
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Journal of oncology
Volume/pages
(2012) , 11 p.
ISSN
1687-8450
Article Reference
289315
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Since the Pap test was introduced in the 1940s, there has been an approximately 70% reduction in the incidence of squamous cell cervical cancers in many developed countries by the application of organized and opportunistic screening programs. The efficacy of the Pap test, however, is hampered by high interobserver variability and high false-negative and false-positive rates. The use of biomarkers has demonstrated the ability to overcome these issues, leading to improved positive predictive value of cervical screening results. In addition, the introduction of HPV primary screening programs will necessitate the use of a follow-up test with high specificity to triage the high number of HPV-positive tests. This paper will focus on protein biomarkers currently available for use in cervical cancer screening, which appear to improve the detection of women at greatest risk for developing cervical cancer, including Ki-67, p16 INK 4a, BD ProEx C, and Cytoactiv HPV L1.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/0cb660/8bd57d99.pdf
Handle