Publication
Title
A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population
Author
Abstract
Objective: Mechanisms explaining the relationship between non-alcoholic fatty liver disease (NAFLD), obesity and insulin resistance are poorly understood. A genetic basis has been suggested. We studied the association between the genes patatin-like phospholipase domain-containing protein 3 (PNPLA3) and apolipoprotein C3 (APOC3) and metabolic and histological parameters of NAFLD in obese patients. Design and Methods: Patients underwent a metabolic and liver assessment. If NAFLD was suspected, liver biopsy was proposed. APOC3 variant rs2854117 and PNPLA3 variant rs738409 were genotyped. Results: 470 patients were included (61.1% had liver biopsy). The percentage of patients with non-alcoholic steatohepatitis (NASH) was significantly different according to the PNPLA3 variant. After adjustment for age and body mass index, the PNPLA3 variant was associated with alanine aminotransferase (p<0.001) and aspartate aminotransferase (p<0.001). The PNPLA3 variant was associated with more severe features of steatohepatitis: steatosis (p<0.001), lobular inflammation (p<0.001), and ballooning (p=0.002), but not with liver fibrosis, anthropometry or insulin resistance. No significant difference in liver histology, anthropometric or metabolic parameters was found between carriers and non-carriers of the APOC3 variant. Conclusions: PNPLA3 polymorphism rs738409 is associated with NASH independently of metabolic factors. We found no association between APOC3 gene variant rs2854117 and histological or metabolic parameters of NAFLD.
Language
English
Source (journal)
Obesity. - Silver Spring, Md
Publication
Silver Spring, Md : 2013
ISSN
1930-7381
Volume/pages
21:10(2013), p. 2138-2145
ISI
000325427300024
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 10.04.2013
Last edited 04.04.2017
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