$\alpha$-carbolines"> $\alpha$-carbolines"> "Base effect" in the auto-tandem palladium-catalyzed synthesis of amino-substituted 1-methyl-1H-<tex>$\alpha$</tex>-carbolines - Institutional Repository University of Antwerp
Title
"Base effect" in the auto-tandem palladium-catalyzed synthesis of amino-substituted 1-methyl-1H-<tex>$\alpha$</tex>-carbolines "Base effect" in the auto-tandem palladium-catalyzed synthesis of amino-substituted 1-methyl-1H-<tex>$\alpha$</tex>-carbolines
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Washington, D.C. ,
Subject
Chemistry
Source (journal)
Organic letters / American Chemical Society. - Washington, D.C.
Volume/pages
15(2013) :5 , p. 1060-1063
ISSN
1523-7060
ISI
000315707400022
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
An auto-tandem Pd-catalyzed process consisting of an intramolecular direct arylation and an intermolecular BuchwaldHartwig reaction for C-ring amino-substituted 1-methyl-1H-α-carboline synthesis has been developed. A mechanistic study of the direct arylation reaction revealed a rate effect of the inorganic base on the CH activation step (base effect). The amines, reagents in the tandem protocol, appear to have a similar effect on the direct arylation.
E-info
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000315707400022&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000315707400022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000315707400022&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle