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Title
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"Base effect" in the auto-tandem palladium-catalyzed synthesis of amino-substituted 1-methyl-1H--carbolines
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Author
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Abstract
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| An auto-tandem Pd-catalyzed process consisting of an intramolecular direct arylation and an intermolecular BuchwaldHartwig reaction for C-ring amino-substituted 1-methyl-1H-α-carboline synthesis has been developed. A mechanistic study of the direct arylation reaction revealed a rate effect of the inorganic base on the CH activation step (base effect). The amines, reagents in the tandem protocol, appear to have a similar effect on the direct arylation. |
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Language
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English
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Source (journal)
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Organic letters / American Chemical Society. - Washington, D.C.
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Publication
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Washington, D.C.
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2013
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ISSN
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1523-7060
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DOI
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10.1021/OL400064R
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Volume/pages
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15
:5
(2013)
, p. 1060-1063
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ISI
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000315707400022
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Full text (Publisher's DOI)
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