Publication
Title
"Base effect" in the auto-tandem palladium-catalyzed synthesis of amino-substituted 1-methyl-1H--carbolines
Author
Abstract
An auto-tandem Pd-catalyzed process consisting of an intramolecular direct arylation and an intermolecular BuchwaldHartwig reaction for C-ring amino-substituted 1-methyl-1H-α-carboline synthesis has been developed. A mechanistic study of the direct arylation reaction revealed a rate effect of the inorganic base on the CH activation step (base effect). The amines, reagents in the tandem protocol, appear to have a similar effect on the direct arylation.
Language
English
Source (journal)
Organic letters / American Chemical Society. - Washington, D.C.
Publication
Washington, D.C. : 2013
ISSN
1523-7060
Volume/pages
15:5(2013), p. 1060-1063
ISI
000315707400022
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 10.04.2013
Last edited 02.08.2017
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