Title
Incidence of hypo- and hyper-capnia in a cross-sectional European cohort of ventilated newborn infants
Author
Contributor
Van Reempts, P.
et al.
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
Archives of disease in childhood : fetal and neonatal edition. - London, 1988, currens
Volume/pages
(2012) , 5 p.
ISSN
1359-2998
1468-2052
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Objective To determine the incidence of hypo- and hyper-capnia in a European cohort of ventilated newborn infants. Design and setting Two-point cross-sectional prospective study in 173 European neonatal intensive care units. Patients and methods Patient characteristics, ventilator settings and measurements, and blood gas analyses were collected for endotracheally ventilated newborn infants on two separate dates. Results A total of 1569 blood gas analyses were performed in 508 included patients with a mean±SD Pco2 of 48±12&#8197;mm&#8197;Hg or 6.4±1.6&#8197;kPa (range 17104&#8197;mm&#8197;Hg or 2.313.9&#8197;kPa). Hypocapnia (Pco2<30&#8197;mm&#8197;Hg or 4&#8197;kPa) and hypercapnia (Pco2>52&#8197;mm&#8197;Hg or 7&#8197;kPa) was present in, respectively, 69 (4%) and 492 (31%) of the blood gases. Hypocapnia was most common in the first 3&#8197;days of life (7.3%) and hypercapnia after the first week of life (42.6%). Pco2 was significantly higher in preterm infants (49&#8197;mm&#8197;Hg or 6.5&#8197;kPa) than term infants (43&#8197;mm&#8197;Hg or 5.7&#8197;kPa) and significantly lower during pressure-limited ventilation (47&#8197;mm&#8197;Hg or 6.3±1.6&#8197;kPa) compared with volume-targeted ventilation (51&#8197;mm&#8197;Hg or 6.8±1.7&#8197;kPa) and high-frequency ventilation (50&#8197;mm&#8197;Hg or 6.7±1.7&#8197;kPa). Conclusions This study shows that hypocapnia is a relatively uncommon finding during neonatal ventilation. The higher incidence of hypercapnia may suggest that permissive hypercapnia has found its way into daily clinical practice.
E-info
https://repository.uantwerpen.be/docman/iruaauth/af2c91/167f8290af7.pdf
Handle