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Title
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Unravelling intracellular immune dysfunctions in chronic fatigue syndrome : interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance
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Author
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Abstract
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| This study examined possible interactions between immunological abnormalities and symptoms in CFS. Sixteen CFS patients filled in a battery of questionnaires, evaluating daily functioning, and underwent venous blood sampling, in order to analyse immunological abnormalities. Ribonuclease (RNase) L cleavage was associated with RNase L activity (rs=0.570; p=0.021), protein kinase R (PKR) (rs=0.716; p=0.002) and elastase activity (rs=0.500; p=0.049). RNase L activity was related to elastase (rs=0.547; p=0.028) and PKR activity (rs=0.625; p=0.010). RNase L activity (rs=0.535; p=0.033), elastase activity (rs=0.585; p=0.017) and RNase L cleavage (rs=0.521; p=0.038) correlated with daily functioning. This study suggests that in CFS patients an increase in elastase activity and subsequent RNase L cleavage is accompanied by increased activity of both the PKR and RNase L enzymes. RNase L and elastase activity are related to daily functioning, thus evidence supporting the clinical importance of these immune dysfunctions in CFS patients was provided. |
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Language
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English
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Source (journal)
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In vivo: the business and medicine report. - Norwalk, Conn.
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Publication
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Norwalk, Conn.
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2008
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ISSN
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0258-851X
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Volume/pages
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22
:1
(2008)
, p. 115-121
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ISI
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000253841300020
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