Title
Unravelling intracellular immune dysfunctions in chronic fatigue syndrome : interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance Unravelling intracellular immune dysfunctions in chronic fatigue syndrome : interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Norwalk, Conn. ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
In vivo: the business and medicine report. - Norwalk, Conn.
Volume/pages
22(2008) :1 , p. 115-121
ISSN
0258-851X
ISI
000253841300020
Carrier
E
Target language
English (eng)
Abstract
This study examined possible interactions between immunological abnormalities and symptoms in CFS. Sixteen CFS patients filled in a battery of questionnaires, evaluating daily functioning, and underwent venous blood sampling, in order to analyse immunological abnormalities. Ribonuclease (RNase) L cleavage was associated with RNase L activity (rs=0.570; p=0.021), protein kinase R (PKR) (rs=0.716; p=0.002) and elastase activity (rs=0.500; p=0.049). RNase L activity was related to elastase (rs=0.547; p=0.028) and PKR activity (rs=0.625; p=0.010). RNase L activity (rs=0.535; p=0.033), elastase activity (rs=0.585; p=0.017) and RNase L cleavage (rs=0.521; p=0.038) correlated with daily functioning. This study suggests that in CFS patients an increase in elastase activity and subsequent RNase L cleavage is accompanied by increased activity of both the PKR and RNase L enzymes. RNase L and elastase activity are related to daily functioning, thus evidence supporting the clinical importance of these immune dysfunctions in CFS patients was provided.
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