Title
Effect of TENS on pain in relation to central sensitization in patients with osteoarthritis of the knee : study protocol of a randomized controlled trial Effect of TENS on pain in relation to central sensitization in patients with osteoarthritis of the knee : study protocol of a randomized controlled trial
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Trials
Volume/pages
13(2012) :1 , p. 21-
ISSN
1745-6215
ISI
000301738400001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
BACKGROUND: Central sensitization has recently been documented in patients with knee osteoarthritis (OAk). So far, the presence of central sensitization has not been considered as a confounding factor in studies assessing the pain inhibitory effect of tens on osteoarthritis of the knee. The purpose of this study is to explore the pain inhibitory effect of burst tens in OAk patients and to explore the prognostic value of central sensitization on the pain inhibitory effect of tens in OAk patients. METHODS: Patients with knee pain due to OAk will be recruited through advertisements in local media. Temporal summation, before and after a heterotopic noxious conditioning stimulation, will be measured. In addition, pain on a numeric rating score, WOMAC subscores for pain and function and global perceived effect will be assessed. Patients will be randomly allocated to one of two treatment groups (tens, sham tens). Follow-up measurements will be scheduled after a period of 6 and 12 weeks. DISCUSSION: Tens influences pain through the electrical stimulation of low-threshold A-beta cutaneous fibers. The responsiveness of central pain-signaling neurons of centrally sensitized OAk patients may be augmented to the input of these electrical stimuli. This would encompass an adverse therapy effect of tens. To increase treatment effectiveness it might be interesting to identify a subgroup of symptomatic OAk patients, i.e., non-sensitized patients, who are likely to benefit from burst tens. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01390285.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/c91e56/7284.pdf
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