Title
Between-family variation and quantitative genetics of developmental instability of long bones in rabbit foetuses
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
London ,
Subject
Biology
Source (journal)
Biological journal of the Linnean Society. - London
Volume/pages
109(2013) :1 , p. 33-42
ISSN
0024-4066
ISI
000317354800003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The genetic basis of developmental instability (DI) remains largely unknown as a result of its morphological expression, fluctuating asymmetry (FA), poorly reflecting DI, especially if few traits are studied. The typically low values of heritability of FA (h2FA) can be translated into higher values of DI (h2DI) by the hypothetical repeatability, yet leading to wide confidence intervals. Thus, high sample sizes and/or several traits are indispensible for reaching meaningful conclusions. To obtain more insights into quantitative genetic variation of DI, we investigated between-family variance in DI in six long bones of 1126 foetuses of the New Zealand white rabbit from a full-sib experiment. We applied different approaches to obtain genetic parameters for DI. Heritabilities and the coefficients of between-family variation (CVB) were calculated for six individual traits and composite indices. The results obtained, despite a likely upward bias as a result of maternal and non-additive effects, lend support to the presence of moderate additive genetic variance for DI. It is suggested that, in foetal traits, the environmental variance was minimal, leading to a high likelihood of detecting genetic variation in DI, thus creating an ideal model system for studying the genetic basis of DI.
E-info
https://repository.uantwerpen.be/docman/iruaauth/370c67/deb51b12888.pdf
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