Title
Towards a solution for performance related confounds : frontal, striatal and parietal activation during a continuous spatiotemporal working memory manipulation task Towards a solution for performance related confounds : frontal, striatal and parietal activation during a continuous spatiotemporal working memory manipulation task
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Brain Imaging and Behavior
Volume/pages
7(2013) :1 , p. 85-90
ISSN
1931-7557
ISI
000315466200009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Working memory plays a role in various forms of psychopathology. However, working memory consists of multiple theoretical components that may be differently taxed by various specific types of task, and brain activation differences between patients and healthy controls may result from differences in task performance. This makes it difficult to interpret such results in terms of disease-related dysfunctions in affected regions or networks. The aim of the current study was to determine the brain activation related to the updating of spatiotemporal content of working memory, in such a way that performance-related confounds in future clinical studies would be minimized. Nineteen healthy volunteers performed a task involving a continuous updating process during fMRI measurement. A frontostriatal network including medial and lateral prefrontal cortex, inferior frontal cortex, premotor cortex, supplementary motor cortex, thalamus and putamen was found to be related to the updating process. The results constrain the set of brain regions plausibly related to the specific updating component of working memory. Further, the task design may be of use in future studies of pathological conditions such as schizophrenia due to the minimization of potential confounds.
E-info
https://repository.uantwerpen.be/docman/iruaauth/322c97/d7b3744.pdf
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