Publication
Title
Long-term follow-up after percutaneous coronary intervention with polytetrafluoroethylene-covered stents compared to bare metal stents, with and without embolic protection, in diseased saphenous vein grafts
Author
Abstract
Objectives The long-term clinical outcome of covered stents in the percutaneous treatment of diseased saphenous vein graft (SVG) has been disappointing. The single self-expanding polytetrafluoroethylene (PTFE)-covered Symbiot stent with a unique profile may present advantages that translate into superior long-term clinical outcomes. This study evaluated the safety, effectiveness and clinical outcome of the Symbiot (TM) covered stent system (Boston Scientific, Natick, Mass.) and FilterWire (TM) EX (Boston Scientific, Natick, Mass.) versus bare metal stents (BMS) in SVG intervention. Methods and results Between January 2003 and August 2005, 90 patients with degenerative SVG lesions were prospectively randomized at 6 study sites to Symbiot implantation (n=30), BMS with FilterWire as embolic protection device (EPD, n=30), or BMS without EPD (control group, n=30). The primary end point was reduction in peri-procedural cardiac enzyme rise. The major secondary end points were in-hospital, 6-month and long-term target vessel failure rates, defined as the cumulative of death, myocardial infarction and clinically driven target lesion revascularization. There was no significant reduction in median [IQR] post-procedural troponin-I rise in the Symbiot group compared to the FilterWire or the control group (0.08 [0-1.40] mu g/l; 0.06 [0-0.28] mu g/l; and 0.04 [0-0.31] mu g/l, P=0.58). At 7.4 +/- 1.3 (mean +/- SD) years, there were numerically less deaths in the Symbiot group, although this did not reach statistical significance (P=0.20). There was no significant difference in TVF-free survival between the treatment groups (P=0.98). Conclusion This study failed to show a procedural or long-term clinical advantage for the Symbiot PTFE-covered stent in the treatment of degenerated SVG.
Language
English
Source (journal)
Acta cardiologica. - Bruxelles
Publication
Bruxelles : 2013
ISSN
0001-5385
Volume/pages
68:1(2013), p. 1-9
ISI
000315178300001
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 30.04.2013
Last edited 20.09.2017
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