Publication
Title
M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
Author
Abstract
Background: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. Findings: To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding. Conclusions: M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.
Language
English
Source (journal)
Retrovirology. - London
Publication
London : 2013
ISSN
1742-4690
Volume/pages
10:12(2013), p. 1-9
Article Reference
12
ISI
000314831400002
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
[E?say:metaLocaldata.cgzprojectinf]
Combined highly active anti-retroviral microbicides (CHAARM).
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 30.04.2013
Last edited 04.10.2017
To cite this reference