Title
M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
Retrovirology. - London
Volume/pages
10(2013) :12 , p. 1-9
ISSN
1742-4690
Article Reference
12
ISI
000314831400002
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. Findings: To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding. Conclusions: M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/e2dd45/3432.pdf
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