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Title
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M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
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Author
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Abstract
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| Background: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. Findings: To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding. Conclusions: M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission. |
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Language
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English
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Source (journal)
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Retrovirology. - London
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Publication
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London
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2013
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ISSN
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1742-4690
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DOI
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10.1186/1742-4690-10-12
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Volume/pages
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10
:12
(2013)
, p. 1-9
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Article Reference
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12
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ISI
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000314831400002
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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