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Title
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Increased IGF-1 serum levels and discordant protein and mRNA IGF-1 receptor expression in the small intestine of formula-fed piglets
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Author
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Abstract
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| The present investigation addresses the question whether feeding piglets on formulated milk alters the insulin-like growth factor-1 (IGF-1) system differently in normal versus low birth weight piglets. In this study, both types of piglets were either sow-fed until 28 days of age or until 3 days of age and subsequently formula-fed until day 28. Formula-fed piglets had higher serum IGF-1 levels compared to suckled piglets, whereas low birth weight piglets had lower IGF-1 levels in comparison with normal birth weight piglets. In contrast, the mRNA expression of IGF-1 receptor (IGF-1R) showed lower expression in formula-fed piglets versus suckled piglets. However, the opposite effect was observed for IGF-1R protein abundance. Moreover, birth weight did not markedly affect IGF-1R mRNA or protein abundance. In conclusion, formula-fed piglets have higher IGF-1 serum levels and altered gene and protein expression of IGF-1R in the small intestine, irrespective of their birth weight. |
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Language
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English
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Source (journal)
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Livestock science. - Amsterdam, 2006, currens
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Publication
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Amsterdam
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2013
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ISSN
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1871-1413
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DOI
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10.1016/J.LIVSCI.2013.03.009
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Volume/pages
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154
:1-3
(2013)
, p. 224-228
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ISI
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000319852200030
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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