Infliximab induces remission in cryptogenic multifocal ulcerous stenosing enteritis : first caseInfliximab induces remission in cryptogenic multifocal ulcerous stenosing enteritis : first case
Faculty of Medicine and Health Sciences
Laboratory Experimental Medicine and Pediatrics (LEMP)
World journal of gastroenterology. -
19(2013):10, p. 1661-1664
University of Antwerp
We present the case of a 29-year-old patient with a history of abdominal pain and vomiting. Based on wireless video capsule findings he was previously diagnosed with ileal Crohn's disease at a different institution, although the clinical and radiological picture was not typical and the response to corticosteroids was poor. We performed a single-balloon enteroscopy showing a short, ulcerous stenosis 50 cm proximal from Bauhin's valve. The endoscopic and clinical histopathological findings were compatible with cryptogenic multifocal ulcerous stenosing enteritis (CMUSE). High dose corticosteroids were again started, without effect. The monoclonal tumor necrosis factor-alpha (TNF-alpha) antibody infliximab was added to the medical therapy. After induction therapy, both clinical and endoscopic amelioration was obtained. Larger case studies are needed to confirm the efficacy of TNF-alpha inhibition in steroid refractory CMUSE. (c) 2013 Baishideng. All rights reserved.