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Title
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Reperfusion of liver graft during transplantation : techniques used in transplant centres within Eurotransplant and meta-analysis of the literature
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Author
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Abstract
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| It remains unclear which liver graft reperfusion technique leads to the best outcome following transplantation. An online survey was sent to all transplant centres (n=37) within Eurotransplant (ET) to collect information on their technique used for reperfusion of liver grafts. Furthermore, a systematic review of all literature was performed and a meta-analysis was conducted based on patients' mortality, number of retransplantations and incidence of biliary complications, depending on the technique used. Of the 28 evaluated centres, 11 (39%) reported performing simultaneous reperfusion (SIMR), 13 (46%) perform initial portal vein reperfusion (IPR), 1 (4%) performs an initial hepatic artery reperfusion (IAR) and 3 (11%) perform retrograde reperfusion (RETR). In 21 centres (75%), one reperfusion technique is used as a standard, but in only one centre is this decision based on available literature. Twenty centres (71%) said they would agree to participate in randomized controlled trials (RCT) if required. For meta-analysis, IAR vs. IPR, SIMR vs. IPR and RETR vs. IPR were compared. There was no difference between any of the techniques compared. There is no consensus on a preferable reperfusion technique. Available evidence does not help in the decision-making process. There is thus an urgent need for multicentric RCTs. |
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Language
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English
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Source (journal)
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Transplant international. - Heidelberg, 1988
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Publication
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Heidelberg
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2013
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ISSN
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0934-0874
[print]
1432-2277
[online]
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DOI
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10.1111/TRI.12083
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Volume/pages
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26
:5
(2013)
, p. 508-516
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ISI
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000318049000011
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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