Title
Association of atherosclerosis with presence and progression of osteoarthritis : the Rotterdam Study Association of atherosclerosis with presence and progression of osteoarthritis : the Rotterdam Study
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London :British Medical Association ,
Subject
Human medicine
Source (journal)
Annals of the rheumatic diseases / European League Against Rheumatism [Kilchberg] - London, 1939, currens
Volume/pages
72(2013) :5 , p. 646-651
ISSN
0003-4967
ISI
000317050400013
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Objective This study examined whether vascular alterations are associated with the presence and progression of osteoarthritis of the knee, the hip and the different hand joints in a large prospective cohort study. Methods In this population-based study involving participants aged 55 years and older (Rotterdam Study I), men (n = 2372) and women (n = 3278) were analysed separately. x-Rays of the knee, hip and hand were scored using the Kellgren and Lawrence score for osteoarthritis at baseline, after 6.6 years and 10 years. Measures of atherosclerosis (carotid intima media thickness (IMT) and carotid plaque) and data on covariates (age, body mass index, hypertension, cholesterol ratio, diabetes mellitus and smoking) were collected at baseline. Multivariate logistic regression models with generalised estimated equations were used to calculate OR and corresponding 95% CI. Secondary multiple comparison adjustment resulted in a significance level of p < 0.0021. Results In women, IMT showed an independent association with the prevalence of knee osteoarthritis (adjusted OR (aOR) 1.7, 1.1 to 2.7), and carotid plaque with distal interphalangeal (DIP) osteoarthritis (aOR 1.4, 1.2 to 1.7) and with metacarpophalangeal osteoarthritis (aOR 1.5, 1.1 to 2.2). An independent association for IMT with progression of metacarpophalangeal osteoarthritis was found in women (aOR 2.9, 1.18 to 6.93). Additional adjustment for multiple testing yielded a signifi cant association between carotid plaque and DIP osteoarthritis in women (p < 0.001). Conclusions This study showed independent associations of atherosclerosis with osteoarthritis of the knee and hand joints in women. The evidence was most solid for a relation with DIP osteoarthritis. More research is needed to confirm the associations and examine the differential association with various joints.
E-info
https://repository.uantwerpen.be/docman/iruaauth/2c8287/36f3695.pdf
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Handle