Title
Ultrasound leaching-dispersive liquid-liquid microextraction based on solidification of floating organic droplet for determination of polybrominated diphenyl ethers in sediment samples by gas chromatography-tandem mass spectrometry Ultrasound leaching-dispersive liquid-liquid microextraction based on solidification of floating organic droplet for determination of polybrominated diphenyl ethers in sediment samples by gas chromatography-tandem mass spectrometry
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Amsterdam ,
Subject
Chemistry
Biology
Source (journal)
Journal of chromatography: A. - Amsterdam
Volume/pages
1285(2013) , p. 15-21
ISSN
0021-9673
ISI
000317167400003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Ultrasound leaching-dispersive liquid-liquid microextraction using solidification of floating organic droplet (USL-DLLME-SFO) technique is proposed for extraction and isolation of polybrominated diphenyl ethers (PBDEs) from sediment and further determination by gas chromatography-tandem mass spectrometry (GC-MS/MS). Parameters that affect the efficiency of the procedure were investigated by a full factorial (2(k)) screening design. Variables showing significant effects on the analytical responses were considered within a further central composite design (CCD). The optimization assays have led to following protocol: ultrasound assisted lixiviation of 1 g sediment was carried out by using 1.2 mL MeOH. Further, the analytes were isolated from 0.4 mL of the extract using the DLLME-SFO technique. The microextraction was performed using 0.1 mL MeOH, 22 mg 1-dodecanol, 1 mL NaCl solution 6.15 M and 4.4 mL ultrapure water as dispersive and extracting solvents, medium ionic strength and dispersant bulk, respectively. Under optimum conditions, the method exhibits good performance in terms of linearity and precision (RSD < 9.2%), with recoveries above 71% and limits of detection (LODs) within the range 0.5-1.8 pg g(-1) dry weight (d.w.). Method validation was demonstrated through the analysis of environmental sediment samples in which PBDEs were detected and quantified. The presence of BDE-47, -100, -99 and -153 was reported within the concentration range of <LOD to 29 pg g(-1) d.w. The proposed methodology constitutes a suitable approach for the analysis of PBDEs in complex solid samples requires minimum organic solvents consumption, sample manipulation, and increases sample throughput. (C) 2013 Elsevier B.V. All rights reserved.
E-info
https://repository.uantwerpen.be/docman/iruaauth/8507a5/47f3716.pdf
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