Title
Hyperlactatemia and concurrent use of antiretroviral therapy among HIV infected patients in Uganda Hyperlactatemia and concurrent use of antiretroviral therapy among HIV infected patients in Uganda
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
African health sciences
Volume/pages
12(2012) :3 , p. 268-275
ISSN
1680-6905
ISI
000316932900005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: We determined the prevalence and factors associated with hyperlactatemia among HIV patients admitted on the emergency ward of a national hospital in Uganda. Objective: We were specifically interested in knowing whether there was an association between clinically significant hyperlactatemia and concurrent antiretroviral therapy (ART) use. Methods: A cross sectional descriptive study enrolled 303 HIV infected patients at a national referral hospital between March and April 2008. We consecutively recruited all eligible HIV infected patients above 18 years admitted on the emergency ward. Data were collected on socio-demographic, clinical and laboratory characteristics. Lactate levels were measured using the Accutrend (R) portable lactate analyser. Data analysis was performed using Stata 10.0; P-value of <0.05 was considered to be significant. Results: Three hundred and three HIV infected patients were recruited. Prevalence of hyperlactatemia (lactate >= 2.5mmol/L) was 252 (83.2%). Clinically significant hyperlactatemia (lactate >= 4mmol/L) was present in 105/303(34.6%) patients. There was no association between use of ART and clinically significant hyperlactatemia. In the multivariate analysis, body weakness 1.91 (1.09-3.35), skin rash 3.18 (1.11-9.10) and tachypnoea 1.04 (1.01-1.07) were independently associated with clinically significant hyperlactatemia. Conclusion: There was a high prevalence of clinically significant hyperlactatemia among HIV infected patients but it was not associated with concurrent antiretroviral use. African Health Sciences 2012; 12(3): 268 - 275 http://dx.doi.org/10.4314/ahs.v12i3.4
Full text (open access)
https://repository.uantwerpen.be/docman/irua/eccab3/3839.pdf
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