Title
M cell specific markers in man and domestic animals : valuable tools in vaccine development M cell specific markers in man and domestic animals : valuable tools in vaccine development
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Veterinary Sciences
Publication type
article
Publication
Oxford ,
Subject
Biology
Veterinary medicine
Human medicine
Source (journal)
Comparative immunology, microbiology and infectious diseases. - Oxford
Volume/pages
36(2013) :4 , p. 353-364
ISSN
0147-9571
ISI
000321420100002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
M cells play a pivotal role in the induction of immune responses within the mucosa-associated lymphoid tissues. As such, they are frequently studied for the development of mucosal vaccines. Unfortunately, the lack of a universal M cell marker hampers the progress in this field since researchers need species- and tissue-specific markers in order to isolate, identify or target M cells. Depicting the most appropriate M cell marker for the species and tissue under investigation might, however, be complicated by the numerous publications on this topic, often mentioning both positive and negative results for the tested marker. Therefore, this review gives an overview of the specific M cell markers in man and various domestic and laboratory animals. In addition, current state-of-the-art as regards the use of M cell models and markers in mucosal vaccine development is discussed.
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