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Title
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Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades
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Author
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Abstract
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| The enantioselective synthesis of heavily decorated spirolactams has been accomplished via an arylative or vinylative allene carbocyclisation cascade. Mediated by silver phosphate, a range of allene-linked pro-nucleophiles and aryl or vinyl iodides were reacted in the presence of catalytic Pd(OAc)(2) and chiral bis-(oxazoline) ligands to afford the spirolactam products in good yields and high enantio-and diastereoselectivities. |
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Language
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English
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Source (journal)
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Chemical communications / Royal Society of Chemistry [London] - London, 1996, currens
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Publication
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London
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Royal Society of Chemistry
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2013
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ISSN
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1359-7345
[print]
1364-548X
[online]
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DOI
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10.1039/C3CC42079E
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Volume/pages
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49
:46
(2013)
, p. 5265-5267
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ISI
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000318917900006
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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