Title
Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
London ,
Subject
Chemistry
Source (journal)
ChemComm. - London, 1996, currens
Volume/pages
49(2013) :46 , p. 5265-5267
ISSN
1359-7345
1364-548X
ISI
000318917900006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The enantioselective synthesis of heavily decorated spirolactams has been accomplished via an arylative or vinylative allene carbocyclisation cascade. Mediated by silver phosphate, a range of allene-linked pro-nucleophiles and aryl or vinyl iodides were reacted in the presence of catalytic Pd(OAc)(2) and chiral bis-(oxazoline) ligands to afford the spirolactam products in good yields and high enantio-and diastereoselectivities.
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