Title
In vitro antiprotozoal activity of triterpenoid constituents of **Kleinia odora** growing in Saudi Arabia
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Bazel ,
Subject
Chemistry
Biology
Human medicine
Source (journal)
Molecules: a journal of synthetic chemistry and natural product chemistry. - Bazel
Volume/pages
18(2013) :8 , p. 9207-9218
ISSN
1420-3049
ISI
000330304100033
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Two lupane and four ursane triterpenes, namely epilupeol (1), lupeol acetate (2), ursolic acid (3), brein (4), 3β 11α-dihydroxy urs-12-ene (5) and ursolic acid lactone (6) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 36 were isolated for the first time from K. odora. The triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxicity was determined against MRC-5 fibroblasts to assess selectivity. The ursane triterpenes were found to be active against more than one type of the tested parasites, with the exception of compound 6. This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum, L. infantum, T. cruzi, and T. brucei.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/d6e14d/c9f8818e.pdf
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