Title
Perspectives on the reduction in cardiovascular mortality with oral appliance therapy for patients with severe OSA intolerant to CPAP : editorial Perspectives on the reduction in cardiovascular mortality with oral appliance therapy for patients with severe OSA intolerant to CPAP : editorial
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oxford ,
Subject
Human medicine
Source (journal)
Respirology. - Oxford
Volume/pages
18(2013) :8 , p. 1161-1162
ISSN
1323-7799
ISI
000326177100001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Obstructive sleep apnea (OSA) is a well-established and independent risk factor for a range of clinical conditions, such as hypertension, stroke and diabetes. Severe OSA (apnea/hypopnea-index (AHI) > 30/h) significantly increases the risk of cardiovascular mortality. Continuous positive airway pressure (CPAP) is considered the standard of care for patients with severe OSA and an effective treatment with CPAP reduces the risk of OSA-related cardiovascular morbidity and mortality. Oral appliance therapy, particularly with appliances that reduce upper airway collapse by advancing the mandible (OAm), is indicated for the management of patients with mild to moderate OSA and can be prescribed as a second-line treatment for patients with severe OSA who do not comply with or refuse CPAP. In literature there is increasing evidence for the beneficial effect of OAm therapy on OSA-related cardiovascular morbidity.
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