Title
Phytochemical, antimicrobial and antiprotozoal evaluation of **Garcinia mangostana** pericarp and <tex>$\alpha$</tex>-mangostin, its major xanthone derivative Phytochemical, antimicrobial and antiprotozoal evaluation of **Garcinia mangostana** pericarp and <tex>$\alpha$</tex>-mangostin, its major xanthone derivative
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Bazel ,
Subject
Chemistry
Biology
Source (journal)
Molecules: a journal of synthetic chemistry and natural product chemistry. - Bazel
Volume/pages
18(2013) :9 , p. 10599-10608
ISSN
1420-3049
ISI
000330306600034
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garcinia mangostana. Dichloromethane, ethyl acetate extract and the major xanthone (α-mangostin) were evaluated in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. The major constituent α-mangostin was also checked for antimicrobial potential against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Bacillius subtilis, Staphylococcus aureus, Mycobacterium smegmatis, M. cheleneoi, M. xenopi and M. intracellulare. Activity against P. falciparum (IC50 2.7 μg/mL) and T. brucei (IC50 0.5 μg/mL) were observed for the dichloromethane extract, however, with only moderate selectivity was seen based on a parallel cytotoxicity evaluation on MRC-5 cells (IC50 9.4 μg/mL). The ethyl acetate extract was inactive (IC50 > 30 µg/mL). The major constituent α-mangostin showed rather high cytotoxicity (IC50 7.5 µM) and a broad but non-selective antiprotozoal and antimicrobial activity profile. This in vitro study endorses that the antiprotozoal and antimicrobial potential of prenylated xanthones is non-conclusive in view of the low level of selectivity.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/0084b1/5ffb3900.pdf
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