Title
No important role for genetic variation in the Chibby gene in monogenic and complex obesity No important role for genetic variation in the Chibby gene in monogenic and complex obesity
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Dordrecht ,
Subject
Chemistry
Biology
Source (journal)
Molecular biology reports. - Dordrecht
Volume/pages
40(2013) :7 , p. 4491-4498
ISSN
0301-4851
ISI
000320674700044
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Chibby (CBY) has been identified as a potent proadipogenic factor required for adipocyte differentiation. It has been shown that CBY inhibits the canonical Wnt pathway, and therefore promotes the development of new fat cells. Our objective therefore is to investigate the contribution of rare and common genetic variation in CBY to the development of human obesity. A mutation analysis was performed on a total of 566 obese patients and 432 lean individuals. To investigate the involvement of CBY in complex obesity, we performed a genetic association analysis of the entire CBY gene region on 1,011 obese individuals and 523 control samples. Four rare, novel variants were identified in either obese patients or lean control subjects, among which two non-synonymous variations and one frameshift mutation. In addition, four previously reported CBY variants were found. In the association analysis, logistic and linear regression showed no association between common genetic variation in CBY and obesity parameters. Several novel variations were found, but no definite role in the pathogenesis of obesity could be confirmed. Results from the association analysis suggest that common variation in CBY is not a cause for obesity in the Belgian population.
E-info
https://repository.uantwerpen.be/docman/iruaauth/6e5833/5b24543.pdf
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