Publication
Title
Efficacy of different albendazole and mebendazole regimens against heavy-intensity **Trichuris trichiura** infections in school children, Jimma Town, Ethiopia
Author
Abstract
Recent studies have shown that the efficacy of benzimidazole drugs is influenced by the intensity of trichuriasis. Therefore, the objective of this study was to determine the efficacy of albendazole (ALB) and mebendazole (MBZ) administered randomly for 1 (ALB x 1 and MBZ x 1) or 2 days (ALB x 2 and MBZ x 2) to 385 school children with heavy-intensity trichuriasis (mean faecal egg counts (FEC) > 1000 eggs per gram of stool (epg)) in Jimma Town, Ethiopia. The efficacies (95% confidence intervals) by means of reduction in faecal egg counts (FECs) were 29.3% (-9.9-56.2), 60.0% (48.5-70.9), 73.5% (64.2-81.3), and 87.1% (81.4-91.2) for ALB x 1, MBZ x 1, ALB x 2, and MBZ x 2, respectively. These observations highlight that assessment of the anthelmintic efficacy of existing or new compounds against Trichuris trichiura should be assessed under varying levels of infection intensity.
Language
English
Source (journal)
Pathogens and global health. - London, 2012, currens
Publication
London : 2013
ISSN
2047-7724
Volume/pages
107:4(2013), p. 207-209
ISI
000321119300009
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.09.2013
Last edited 10.11.2017
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