Title
Efficacy of different albendazole and mebendazole regimens against heavy-intensity **Trichuris trichiura** infections in school children, Jimma Town, Ethiopia Efficacy of different albendazole and mebendazole regimens against heavy-intensity **Trichuris trichiura** infections in school children, Jimma Town, Ethiopia
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
Pathogens and global health. - London, 2012, currens
Volume/pages
107(2013) :4 , p. 207-209
ISSN
2047-7724
ISI
000321119300009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Recent studies have shown that the efficacy of benzimidazole drugs is influenced by the intensity of trichuriasis. Therefore, the objective of this study was to determine the efficacy of albendazole (ALB) and mebendazole (MBZ) administered randomly for 1 (ALB x 1 and MBZ x 1) or 2 days (ALB x 2 and MBZ x 2) to 385 school children with heavy-intensity trichuriasis (mean faecal egg counts (FEC) > 1000 eggs per gram of stool (epg)) in Jimma Town, Ethiopia. The efficacies (95% confidence intervals) by means of reduction in faecal egg counts (FECs) were 29.3% (-9.9-56.2), 60.0% (48.5-70.9), 73.5% (64.2-81.3), and 87.1% (81.4-91.2) for ALB x 1, MBZ x 1, ALB x 2, and MBZ x 2, respectively. These observations highlight that assessment of the anthelmintic efficacy of existing or new compounds against Trichuris trichiura should be assessed under varying levels of infection intensity.
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