Publication
Title
Native ion mobility-mass spectrometry and related methods in structural biology
Author
Abstract
Mass spectrometry-based methods have become increasingly important in structural biology - in particular for large and dynamic, even heterogeneous assemblies of biomolecules. Native electrospray ionization coupled to ion mobility-mass spectrometry provides access to stoichiometry, size and architecture of noncovalent assemblies; while non-native approaches such as covalent labeling and H/D exchange can highlight dynamic details of protein structures and capture intermediate states. In this overview article we will describe these methods and highlight some recent applications for proteins and protein complexes, with particular emphasis on native MS analysis. This article is part of a Special Issue entitled: Mass spectrometry in structural biology. (C) 2012 Elsevier B.V. All rights reserved.
Language
English
Source (journal)
Biochimica et biophysica acta : proteins and proteomics. - Amsterdam
Publication
Amsterdam : 2013
ISSN
1570-9639
Volume/pages
1834:6(2013), p. 1239-1256
ISI
000320417700032
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.09.2013
Last edited 05.04.2017
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