Title
Neural substrates predicting improvement of tinnitus after cochlear implantation in patients with single-sided deafness
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Hearing research. - Amsterdam
Volume/pages
299(2013) , p. 1-9
ISSN
0378-5955
ISI
000319483700001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Notwithstanding successful reduction of tinnitus after cochlear implantation (CI) in patients with single-sided deafness (SSD) in recent studies, neither the exact mechanism of suppression nor the predictors of the amount of improvement are fully understood yet. We collected quantitative electroencephalography (qEEG) data from nine SSD patients who underwent CI for tinnitus management. By correlating the degree of improvement in tinnitus intensity and tinnitus-related distress with preoperative source-localized qEEG findings and comparing qEEG findings of patients with marked improvement after CI with those with relatively slight improvement with regard to source-localized activity complimented by connectivity analysis, we attempted to find preoperative predictors of tinnitus improvement. Our results showed increased activities of the auditory cortex (AC), posterior cingulate cortex (PCC) and increased functional connectivity between the AC and PCC as negative prognostic factors for the reduction of tinnitus intensity after CI in patients with SSD. Also, relatively increased activity of the right dorsolateral prefrontal cortex and decreased connectivity between distress-related areas such as the orbitofrontal cortex/parahippocampus and sensory-perception areas such as the AC/precuneus were found in patients with relatively slight improvement in tinnitus-related distress as compared with those with marked improvement. The current study suggests that preoperative cortical oscillations can be applied to predict post-CI tinnitus reduction in patients with SSD. (C) 2013 Elsevier B.V. All rights reserved.
E-info
https://repository.uantwerpen.be/docman/iruaauth/ef6a52/3a95509.pdf
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