Title
Peptidomic analysis of human reflex tear fluidPeptidomic analysis of human reflex tear fluid
Author
Faculty/Department
Faculty of Sciences. Biology
Research group
Systemic Physiological and Ecotoxicological Research (SPHERE)
Publication type
article
Publication
Fayetteville, N.Y.,
Subject
Chemistry
Biology
Pharmacology. Therapy
Source (journal)
Peptides. - Fayetteville, N.Y.
Volume/pages
42(2013), p. 63-69
ISSN
0196-9781
0196-9781
ISI
000320492800009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Tear fluid is a complex mixture of biological compounds, including carbohydrates, lipids, electrolytes, proteins, and peptides. Despite the physiological importance of tear fluid, little is known about the identity of its endogenous peptides. In this study, we analyzed and identified naturally occurring peptide molecules in human reflex tear fluid by means of LC-MALDI-TOF-TOF. Tandem MS analyses revealed 30 peptides, most of which have not been identified before. Twenty-six peptides are derived from the proline-rich protein 4 and 4 peptides are derived from the polymeric immunoglobulin receptor. Based on their structural characteristics, we suggest that the identified tear fluid peptides contribute to the protective environment of the ocular surface. (c) 2012 Elsevier Inc. All rights reserved.
E-info
https://repository.uantwerpen.be/docman/iruaauth/5b1db3/a965502.pdf
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