|
Title
|
|
|
|
HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Antimicrobial agents and chemotherapy. - Washington, D.C., 1972, currens
|
|
|
Publication
|
|
|
|
Washington, D.C.
:
American Society for Microbiology
,
2013
|
|
|
ISSN
|
|
|
|
0066-4804
|
|
|
DOI
|
|
|
|
10.1128/AAC.01668-12
|
|
|
Volume/pages
|
|
|
|
57
:2
(2013)
, p. 1053-1056
|
|
|
ISI
|
|
|
|
000313896500050
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|