Publication
Title
The role of prostanoids in urinary bladder physiology
Author
Abstract
Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE2, PGF2α, PGI2, PGD2 and thromboxane A2. High levels of these signaling molecules have been implicatedin both animal models and human studiesin decreased functional bladder capacity and micturition volume and increased voiding contraction amplitude. Thus, inhibition of prostanoid production or the use of prostanoid receptor antagonists, might be a rational way to treat patients with detrusor muscle overactivity. Similarly, prostanoid receptor agonists, or agents that stimulate their production, might have a function in treating bladder underactivity. Although some promising results have been reported, the adverse effects of nonselective cyclooxygenase inhibitors are a major concern that restricts their use in the treatment of functional bladder disorders. Further preclinical and clinical studies are needed before cyclooxygenase inhibitors, prostanoid receptor agonists and antagonists become worthwhile therapeutic tools in this setting.
Language
English
Source (journal)
Nature reviews urology
Publication
2012
ISSN
1759-4812
1759-4820
Volume/pages
9:5(2012), p. 283-290
ISI
000303988800009
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 03.10.2013
Last edited 21.06.2017