Title
Active liquid degassing in microfluidic systems Active liquid degassing in microfluidic systems
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Royal society of chemistry ,
Subject
Chemistry
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
Lab on a chip
Volume/pages
13(2013) :22 , p. 4366-4373
ISSN
1473-0189
ISI
000325946800014
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
We present a method for efficient air bubble removal in microfluidic applications. Air bubbles are extracted from a liquid chamber into a vacuum chamber through a semipermeable membrane, consisting of PDMS coated with amorphous Teflon® AF 1600. Whereas air is efficiently extracted through the membrane, water loss is greatly reduced by the Teflon even at elevated temperatures. We present the water loss and permeability change with the amount of added Teflon AF to the membrane. Also, we demonstrate bubble-free, multiplex DNA amplification using PCR in a PDMS microfluidic device.
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