Title
Therapeutic potential of neuregulin-1 in cardiovascular disease Therapeutic potential of neuregulin-1 in cardiovascular disease
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Oxford :Elsevier sci ltd ,
Subject
Pharmacology. Therapy
Source (journal)
Drug discovery today. - London
Volume/pages
18(2013) :17-18 , p. 836-842
ISSN
1359-6446
1359-6446
ISI
000324719500005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Neuregulin-1 (NRG-1)/ErbB signaling has an indispensable role in cardiac development and in the maintenance of the structural and functional integrity of the human adult heart in health and disease. Several animal studies have now demonstrated the therapeutic effects of NRG-1 during acute cardiac injury and during chronic heart failure, with improvements in cardiac performance and animal survival. Phase I and II clinical trials for chronic heart failure in humans are now in progress.
E-info
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