Title
Antiprotozoal activity of synthetic amino substituted 1-methyl-1H-<tex>$\alpha$</tex>-carbolines Antiprotozoal activity of synthetic amino substituted 1-methyl-1H-<tex>$\alpha$</tex>-carbolines
Author
Faculty/Department
Faculty of Sciences. Chemistry
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Berlin ,
Subject
Chemistry
Pharmacology. Therapy
Source (journal)
Die Pharmazie. - Berlin
Volume/pages
69(2014) :2 , p. 83-85
ISSN
0031-7144
ISI
000334261000001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The antiprotozoal properties of a series of amino substituted 1-methyl-1H--carbolines were investigated in a broad panel of parasites. Various substituents were systematically introduced at various positions on the carbocyclic ring of the parent 1-methyl-1H--carboline. Most compounds showed a potent antiprotozoal activity, although mostly accompanied by cytotoxicity on MRC-5 cells. One compound, containing the same amino-substitution as chloroquine, showed an IC50 against Plasmodium falciparum of 2.37M and was reasonably selective.
E-info
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