Publication
Title
Antiprotozoal activity of synthetic amino substituted 1-methyl-1H--carbolines
Author
Abstract
The antiprotozoal properties of a series of amino substituted 1-methyl-1H--carbolines were investigated in a broad panel of parasites. Various substituents were systematically introduced at various positions on the carbocyclic ring of the parent 1-methyl-1H--carboline. Most compounds showed a potent antiprotozoal activity, although mostly accompanied by cytotoxicity on MRC-5 cells. One compound, containing the same amino-substitution as chloroquine, showed an IC50 against Plasmodium falciparum of 2.37M and was reasonably selective.
Language
English
Source (journal)
Die Pharmazie : an international journal of pharmaceutical sciences. - Berlin, 1946, currens
Publication
Berlin : 2014
ISSN
0031-7144
Volume/pages
69:2(2014), p. 83-85
ISI
000334261000001
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.11.2013
Last edited 11.07.2017
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