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Title
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Antiprotozoal activity of synthetic amino substituted 1-methyl-1H--carbolines
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Author
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Abstract
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| The antiprotozoal properties of a series of amino substituted 1-methyl-1H--carbolines were investigated in a broad panel of parasites. Various substituents were systematically introduced at various positions on the carbocyclic ring of the parent 1-methyl-1H--carboline. Most compounds showed a potent antiprotozoal activity, although mostly accompanied by cytotoxicity on MRC-5 cells. One compound, containing the same amino-substitution as chloroquine, showed an IC50 against Plasmodium falciparum of 2.37M and was reasonably selective. |
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Language
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English
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Source (journal)
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Die Pharmazie : an international journal of pharmaceutical sciences. - Berlin, 1946, currens
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Publication
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Berlin
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2014
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ISSN
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0031-7144
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DOI
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10.1691/PH.2014.3748
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Volume/pages
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69
:2
(2014)
, p. 83-85
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ISI
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000334261000001
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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