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Title
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Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia
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Author
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Abstract
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| Background Relatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia. Methods and Results We first screened sera from 52 idiopathic ataxia patients for binding of serum IgG antibodies to cerebellar neurons. One strong-binding serum was selected for immunoprecipitation and mass spectrometry, which resulted in the identification of contactin-associated protein 2 (CASPR2) as a major antigen. CASPR2 antibodies were then found by a cell-based assay in 9/88 (10%) ataxia patients, compared to 3/144 (2%) multiple sclerosis or dementia controls (p=0.011). CASPR2 is strongly expressed in the cerebellum, only partly in association with voltage-gated potassium channels. Conclusions Prospective studies are now needed to see whether identification of CASPR2 antibodies has relevance for the diagnosis and treatment of idiopathic cerebellar ataxia. |
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Language
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English
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Source (journal)
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Journal of neurology, neurosurgery and psychiatry. - London
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Publication
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London
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2012
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ISSN
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0022-3050
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DOI
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10.1136/JNNP-2011-301506
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Volume/pages
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83
:4
(2012)
, p. 437-440
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ISI
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000301296600021
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Full text (Publisher's DOI)
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Full text (open access)
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