Title
Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
London ,
Subject
Chemistry
Human medicine
Source (journal)
Journal of neurology, neurosurgery and psychiatry. - London
Volume/pages
83(2012) :4 , p. 437-440
ISSN
0022-3050
ISI
000301296600021
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background Relatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia. Methods and Results We first screened sera from 52 idiopathic ataxia patients for binding of serum IgG antibodies to cerebellar neurons. One strong-binding serum was selected for immunoprecipitation and mass spectrometry, which resulted in the identification of contactin-associated protein 2 (CASPR2) as a major antigen. CASPR2 antibodies were then found by a cell-based assay in 9/88 (10%) ataxia patients, compared to 3/144 (2%) multiple sclerosis or dementia controls (p=0.011). CASPR2 is strongly expressed in the cerebellum, only partly in association with voltage-gated potassium channels. Conclusions Prospective studies are now needed to see whether identification of CASPR2 antibodies has relevance for the diagnosis and treatment of idiopathic cerebellar ataxia.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/b05532/0beda540.pdf
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