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Title
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Conformational analysis, solvent-accessible surface and geometric extent of inhibitors and substrates
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Author
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Abstract
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| Peptide ligands are known to often bind in an extended conformation to maximize the contact surface with the receptor. The complementarity of shape and surface is a very important factor contributing to the stability of a ligand receptor complex. In this communication we try to answer the following questions: What is the influence of conformation on the surface area? Do ligands maximize their contact surface with the receptor to increase stability of the complex? |
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Language
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English
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Source (journal)
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Collection of Czechoslovak chemical communications. - Praha
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Publication
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Praha
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2006
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ISSN
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0010-0765
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DOI
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10.1135/CCCC20060842
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Volume/pages
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71
:6
(2006)
, p. 842-858
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ISI
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000238419500008
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Full text (Publisher's DOI)
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