Title
Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Paris ,
Subject
Pharmacology. Therapy
Source (journal)
European journal of medicinal chemistry. - Paris, 1974, currens
Volume/pages
40(2005) :6 , p. 597-606
ISSN
0223-5234
ISI
000229895000009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency. (c) 2005 Elsevier SAS. All rights reserved.
E-info
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