Publication
Title
Inhibitor-based validation of a homology model of the active-site of tripeptidyl peptidase II
Author
Abstract
A homology model of the active site region of tripeptidyl peptidase II (TPP II) was constructed based on the crystal structures of four subtilisin-like templates. The resulting model was subsequently validated by judging expectations of the model versus observed activities fora broad set of prepared TPP II inhibitors. The structure-activity relationships observed for the prepared TPP II inhibitors correlated nicely with the structural details of the TIPP II active site model, supporting the validity of this model and its usefulness for structure-based drug design and pharmacophore searching experiments. (c) 2004 Elsevier Inc. All rights reserved.
Language
English
Source (journal)
Journal of molecular graphics and modelling. - Guildford
Publication
Guildford : 2005
ISSN
1093-3263
Volume/pages
23:5(2005), p. 409-418
ISI
000228442700003
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 11.12.2013
Last edited 16.07.2017