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Title
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Synthesis and conformational study of 3-hydroxy-4-(hydroxymethyl)-1-cyclohexanyl purines and pyrimidines
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Author
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Abstract
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| The cyclohexane nucleosides with a 1,4-relationship between nucleoside base and hydroxymethyl moiety were synthesized using a conjugated addition reaction of the nucleobases to ethyl 1,3-cyclohexadiene-1-carboxylate and hydroboration of the cyclohexenyl precursor. The lack of antiviral activity of the compounds was correlated with the conformation of these nucleosides as deduced from NMR and X-ray analysis. |
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Language
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English
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Source (journal)
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The journal of organic chemistry. - Washington, D.C., 1936, currens
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Publication
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Washington, D.C.
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1997
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ISSN
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0022-3263
[print]
1520-6904
[online]
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DOI
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10.1021/JO962204X
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Volume/pages
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62
:9
(1997)
, p. 2861-2871
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ISI
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A1997WX15900028
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Full text (Publisher's DOI)
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