Title
Hexitol nucleic acids (HNA): Synthesis and properties Hexitol nucleic acids (HNA): Synthesis and properties
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
New York, N.Y. ,
Subject
Chemistry
Biology
Source (journal)
Nucleosides and nucleotides. - New York, N.Y.
Volume/pages
16(1997) :7-9 , p. 973-976
ISSN
0732-8311
ISI
A1997YF53000016
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
While improved alkylation procedures have been worked out for the coupling of purine bases to the anhydrohexitol ring using sulphonate activating groups on the anhydrohexitol ring, the Mitsunobu reaction seems to be the method of choice for synthesis of the pyrimidine analogues. In a mixed sequence context, the anhydrohexitol oligonucleotides still display strong and very selective basepairing properties, with a strong preference for RNA as the complement.
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