|
Title
|
|
|
|
Hexopyranosyl-like oligonucleotides
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Oligonucleotides containing monomers 1-(2,3-dideoxy-beta-D-erythro-hexopyranosyl)thymine; 1-(2,4-dideoxy-beta-D-erythro-hexopyranosyl)thymine; 1-(3,4-dideoxy-beta-D-erythro-hexo-pyranosyl)-thymine; 1-(2,3-dideoxy-alpha-D-erythro-hexopyranosyl)thymine; 1-[2,3-dideoxy-3-C-(hydroxymethyl)-alpha-L-threo-pentopyranosyl]-thymine; and 1,5-anhydro-2,3 -dideoxy-2(thymin-1-yl)-D-arabinohexitol were modeled and synthesized. Only oligonucleotides constructed of 1,5-anhydrohexitol nucleosides are able to hybridize with natural DNA. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
ACS symposium series / American Chemical Society. - Washington, D.C., 1974, currens
| |
|
Publication
|
|
|
|
Washington, D.C.
:
American Chemical Society
,
1994
| |
|
ISSN
|
|
|
|
0097-6156
| |
|
Volume/pages
|
|
|
|
580
(1994)
, p. 80-99
| |
|
ISI
|
|
|
|
A1994BB96P00006
| |
|