Title
Hexopyranosyl-like oligonucleotides Hexopyranosyl-like oligonucleotides
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Milton keynes ,
Subject
Chemistry
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
ACS symposium series / American Chemical Society. - Milton keynes
Volume/pages
580(1994) , p. 80-99
ISSN
0097-6156
ISI
A1994BB96P00006
Carrier
E
Target language
English (eng)
Abstract
Oligonucleotides containing monomers 1-(2,3-dideoxy-beta-D-erythro-hexopyranosyl)thymine; 1-(2,4-dideoxy-beta-D-erythro-hexopyranosyl)thymine; 1-(3,4-dideoxy-beta-D-erythro-hexo-pyranosyl)-thymine; 1-(2,3-dideoxy-alpha-D-erythro-hexopyranosyl)thymine; 1-[2,3-dideoxy-3-C-(hydroxymethyl)-alpha-L-threo-pentopyranosyl]-thymine; and 1,5-anhydro-2,3 -dideoxy-2(thymin-1-yl)-D-arabinohexitol were modeled and synthesized. Only oligonucleotides constructed of 1,5-anhydrohexitol nucleosides are able to hybridize with natural DNA.
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