Title
The AMERE project : enabling real-time detection of radiation effects in individual cells in deep space The AMERE project : enabling real-time detection of radiation effects in individual cells in deep space
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Oxford ,
Subject
Physics
Source (journal)
Planetary and space science. - Oxford
Volume/pages
74(2012) :1 , p. 84-96
ISSN
0032-0633
ISI
000313385600009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
A major concern for long-term deep space missions is the detrimental impact of cosmic radiation on human health. Especially the presence of high-energy particles of high atomic mass (HZE) represents a serious threat. To contribute to a fundamental understanding of space radiation effects and to help improving risk assessment for humans on the Moon, the ESA Lunar Lander mission model payload includes a package dedicated to cell-based radiobiology experiments in the form of an Autonomous Microscope for Examination of Radiation Effects (AMERE). The purpose of this setup is to enable real-time visualization of DNA damage repair in living cells after traversal of HZE particles on the Moon. To assess the feasibility of this challenging experiment, we have analysed the biological and technological demands. In this article, we discuss the experimental concept, the biological considerations and describe the implications for system design. (C) 2012 Elsevier Ltd. All rights reserved.
E-info
https://repository.uantwerpen.be/docman/iruaauth/e1ecd3/8285951.pdf
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