Title
Poly(L-proline) II helix propensities in poly(L-lysine) dendrigraft generations from vibrational Raman optical activity Poly(L-proline) II helix propensities in poly(L-lysine) dendrigraft generations from vibrational Raman optical activity
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Subject
Chemistry
Biology
Source (journal)
Biomacromolecules
Volume/pages
10(2009) :6 , p. 1662-1664
ISSN
1525-7797
ISI
000266860700044
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Vibrational Raman optical activity (ROA), measured as small circularly polarized components in Raman scattering from chiral molecules, was applied to study the backbone conformations of the first five generations Of Poly(L-lysine) dendrigrafts (DGLs) in water. Generation I was found to support predominantly the Poly(L-proline) If (PPII) conformation, the amount of which steadily decreased with increasing generation, with a concomitant increase in other backbone conformations. This behavior may be due to increasing crowding of the lysine side chains, together with suppression of backbone hydration, with increasing branching. In contrast, the ROA spectra of a series of linear poly(L-lysine)s in water show little change with increasing molecular weight. Our results may have implications for the nonimmunogenic properties of DGLs.
E-info
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