Title
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Investigation of the in vivo antioxidative activity of **Cynara scolymus** (artichoke) leaf extract in the streptozotocin-induced diabetic rat
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Author
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Abstract
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The in vivo antioxidant activity of a quantified leaf extract of Cynara scolymus (artichoke) was studied. The aqueous artichoke leaf extract (ALE), containing 1.5% caffeoylquinic acid with chlorogenic acid being most abundant (0.30%), and luteolin-7-O-glucoside as major flavonoid (0.15%), was investigated by evaluating the effect on different oxidative stress biomarkers, after 3 wk oral supplementation in the streptozotocin-induced diabetic rat model. Apart from two test groups (0.2 g ALE/kg BW/day and 1 g ALE/kg BW/day, where BW is body weight), a healthy control group, untreated oxidative stress group, and vitamin E treated group (positive control) were included. A 0.2 g/kg BW/day of ALE decreased oxidative stress: malondialdehyde and 8-hydroxydeoxyguanosine levels significantly diminished, whereas erythrocyte glutathione levels significantly increased. A 1.0 g/kg BW/day ALE did not show higher antioxidant activity. |
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Language
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English
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Source (journal)
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Molecular nutrition and food research. - Weinheim
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Publication
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Weinheim
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2014
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ISSN
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1613-4125
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DOI
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10.1002/MNFR.201300282
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Volume/pages
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58
:1
(2014)
, p. 211-215
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ISI
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000330590100018
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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