Title
Superior sensing performance of multi-walled carbon nanotube-based electrodes to detect unconjugated bilirubin
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Lausanne ,
Subject
Physics
Source (journal)
Thin solid films: an international journal on the science and technology of thin and thick films. - Lausanne
Volume/pages
548(2013) , p. 546-550
ISSN
0040-6090
ISI
000327530300089
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The direct electrochemical behaviour of bilirubin in the physio-pathological concentration range and at physiological pH was investigated by cyclic voltammetry. Nanostructured electrodes with a thin film of multi-walled carbon nanotubes exhibited a higher sensing performance than bare electrodes. The detection limit obtained with nanostructured electrodes (4.2 +/- 0.1 mu M) allows the detection of both normal and pathological levels of bilirubin. Due to its sparse solubility in aqueous solvents, in human fluids bilirubin is found in the form of soluble complex with albumin. Therefore, the nanostructured-sensor response was studied in presence of different concentrations of this protein. A signal weakening was observed with increasing concentrations of albumin due to the decrease of free bilirubin. Finally, bilirubin detection was tested at concentrations typical of newborn jaundice (200-500 mu M) and in the presence of normal albumin levels. A detection limit of 9.4 +/- 0.3 mu M was identified. Since this value is below the minimum critical bilirubin concentration for newborns, our sensor, modified with a thin film of carbon nanotubes, could potentially be used for bilirubin detection in cases of newborn jaundice. (C) 2013 Elsevier B. V. All rights reserved.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/208551/8695.pdf
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