Publication
Title
Synthesis of pyridopyrimidines by palladium-catalyzed isocyanide insertion
Author
Abstract
A new synthetic approach to 4-aminopyrido[2,3-d]pyrimidines and 4-aminopyrido[3,2-d]pyrimidines based on palladium-catalyzed reaction of isocyanides with readily available N-(bromopyridyl)amidines is reported. The target heterocycles were obtained in generally good to excellent yield. For the two regioisomeric pyrimidopyrimidines, we compared our approach involving oxidative addition with the analogous CH activation protocol because both methods have been reported for the synthesis of 4-aminoquinazolines. We found that the CH activation protocol does not allow one to obtain the target pyridopyrimidines, but the imidoylative cross-coupling protocol provided a new entry to the synthesis of these medicinally important scaffolds.
Language
English
Source (journal)
ACS catalysis
Publication
2014
ISSN
2155-5435
Volume/pages
4:1(2014), p. 40-43
ISI
000329472600007
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 20.01.2014
Last edited 28.05.2017
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