Title
Status of active specific immunotherapy for stage II, stage III, and resected stage IV colon cancer Status of active specific immunotherapy for stage II, stage III, and resected stage IV colon cancer
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Philadelphia, Pa ,
Subject
Human medicine
Source (journal)
Current colorectal cancer reports. - Philadelphia, Pa, 2005
Volume/pages
9(2013) :4 , p. 380-390
ISSN
1556-3790
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Colorectal cancer is one of the most prevalent types of cancer worldwide and a leading cause of cancer-related mortality. The reported incidence of recurrent disease increases with the stage, and the 5-year survival rate is poor, especially for tumors with regional spread and for late-stage disease. This has prompted the search for more advanced treatment options, and therefore avenues for clinical testing of rationally designed immunotherapeutic strategies, including vaccination, as adjuvant treatment are being explored. In this review, we discuss the study design and results of the clinical trials that have been conducted using active specific immunotherapy in colorectal cancer, including autologous and allogeneic tumor cell vaccines, peptide vaccines, viral-vector-based vaccines, and dendritic-cell-based vaccines as well as some future recommendations.
E-info
https://repository.uantwerpen.be/docman/iruaauth/901e0a/aba27fd61dc.pdf
Handle