Publication
Title
Plerixafor in poor stem cell mobilizers : the belgian compassionate use program
Author
Abstract
Introduction: Currently available stem cell mobilizing regimens (G-CSF +/- chemotherapy) show high failure rates, especially in heavily pretreated patients. Plerixafor, a new stem cell mobilizing agent blocking the CXCR4-SDF-1 interaction, offers a new strategy for stem cell mobilization, especially in poor mobilizers. This study reports on the outcome of the Belgian compassionate use program (CUP). Materials and methods: Between July 2008 and July 2009, 14 Belgian transplant centres participated in plerixafor CUR In total, 22 poor stem cell mobilizers were included. Patients who previously failed stem cell mobilization received a combination of G-CSF (morning of Day 1-5) and plerixafor (evening of Day 4). Apheresis was performed on Day 5. G-CSF, plerixafor and apheresis were continued until at least 2 x 10(6)/kg CD34+ cells were obtained in a maximum of 3 collections. Results: A mean of 2 plerixafor administrations was needed to reach >= 2 x 10(6)/kg CD34+ cells. The overall cumulative success rate (defined as the proportion of patients achieving a successful collection after a maximum of 3 apheresis days) was 64%. Half of the heavily pretreated patients (>= 3 prior chemotherapy regimens) could be mobilized successfully. Patients who received <= 2 prior chemotherapy regimens mobilized successfully in 75% of the cases. Thirteen patients (59.1%) underwent autologous stem cell transplantation with normal neutrophil and platelet recovery times. Conclusion: For patients failing previous mobilization attempts, the combination of plerixafor and G-CSF is a successful mobilizing strategy, even in poor mobilizers who received >= 3 prior chemotherapy regimens.
Language
English
Source (journal)
Acta clinica Belgica. - Leuven, 1946 - 1997
Publication
Leuven : 2011
ISSN
0001-5512
Volume/pages
66:3(2011), p. 200-204
ISI
000292432300005
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 22.01.2014
Last edited 11.06.2017
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