Title
Immunological mechanisms in the pathophysiology of non-alcoholic steatohepatitis Immunological mechanisms in the pathophysiology of non-alcoholic steatohepatitis
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Chemistry
Source (journal)
International journal of molecular sciences
Volume/pages
14(2013) :10 , p. 19867-19890
ISSN
1422-0067
ISI
000328620900031
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation and hepatocyte injury and constitutes hepatic manifestation of the metabolic syndrome. The pathogenesis of NASH is complex and implicates cross-talk between different metabolically active sites, such as liver and adipose tissue. Obesity is considered a chronic low-grade inflammatory state and the liver has been recognized as being an immunological organ. The complex role of the immune system in the pathogenesis of NASH is currently raising great interest, also in view of the possible therapeutic potential of immunotherapy in NASH. This review focuses on the disturbances of the cells constituting the innate and adaptive immune system in the liver and in adipose tissue.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/2d12ad/6647.pdf
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