Title
The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence : a reviewThe nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence : a review
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam,
Subject
Human medicine
Source (journal)
European neuropsychopharmacology. - Amsterdam
Volume/pages
20(2010):2, p. 69-79
ISSN
0924-977X
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Drug dependence is a chronic brain disease characterized by recurrent episodes of relapse, even when the person is motivated to quit. Relapse is a major problem and new pharmacotherapies are needed to prevent relapse episodes. The nicotinic acetylcholine receptor (nAChR) plays an important role in nicotine dependence, alcohol consumption and cue-induced cocaine craving. Stimulation of the nAChR has been found to alter and modulate cell firing in brain areas important for the maintenance of drug dependence. Varenicline, an α4β2 nAChR partial agonist and an α7 nAChR full agonist registered for the treatment of nicotine dependence, significantly reduces nicotine craving and prevents relapse. In addition, varenicline reduces alcohol consumption in rats. Based on a review of the available literature, we hypothesize a potential role for varenicline in the prevention of relapse in patients recovering from drug dependence other than nicotine dependence.
E-info
https://repository.uantwerpen.be/docman/iruaauth/bad734/5bd663f6a2d.pdf