Title
Varenicline increases striatal dopamine <tex>$D_{2/3}$</tex> receptor binding in rats
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Abingdon ,
Subject
Human medicine
Source (journal)
Addiction biology. - Abingdon, 1996, currens
Volume/pages
14(2009) :4 , p. 500-502
ISSN
1355-6215
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Increasing dopamine D2/3 receptor availability is postulated to be a treatment for drug addiction. Varenicline, an α4β2-nicotinic partial agonist, is effective for nicotine dependence. We hypothesize that varenicline increases dopamine D2/3 receptor availability. Twenty male drug-naïve rats were randomized to varenicline (2 mg/kg) or placebo for 14 days, and then injected with the dopamine D2/3 radiotracer 123I-IBZM. We found significantly higher striatum-to-cerebellum binding ratios in both dorsal and ventral striatum for the varenicline group compared with placebo. Varenicline increases dopamine D2/3 receptor availability in drug-naïve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking.