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Title
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Varenicline increases striatal dopamine receptor binding in rats
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Author
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Abstract
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| Increasing dopamine D2/3 receptor availability is postulated to be a treatment for drug addiction. Varenicline, an α4β2-nicotinic partial agonist, is effective for nicotine dependence. We hypothesize that varenicline increases dopamine D2/3 receptor availability. Twenty male drug-naïve rats were randomized to varenicline (2 mg/kg) or placebo for 14 days, and then injected with the dopamine D2/3 radiotracer 123I-IBZM. We found significantly higher striatum-to-cerebellum binding ratios in both dorsal and ventral striatum for the varenicline group compared with placebo. Varenicline increases dopamine D2/3 receptor availability in drug-naïve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking. |
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Language
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English
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Source (journal)
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Addiction biology. - Abingdon, 1996, currens
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Publication
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Abingdon
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2009
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ISSN
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1355-6215
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DOI
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10.1111/J.1369-1600.2009.00168.X
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Volume/pages
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14
:4
(2009)
, p. 500-502
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ISI
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000269674600014
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Full text (Publisher's DOI)
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