Publication
Title
Varenicline increases striatal dopamine receptor binding in rats
Author
Abstract
Increasing dopamine D2/3 receptor availability is postulated to be a treatment for drug addiction. Varenicline, an α4β2-nicotinic partial agonist, is effective for nicotine dependence. We hypothesize that varenicline increases dopamine D2/3 receptor availability. Twenty male drug-naïve rats were randomized to varenicline (2 mg/kg) or placebo for 14 days, and then injected with the dopamine D2/3 radiotracer 123I-IBZM. We found significantly higher striatum-to-cerebellum binding ratios in both dorsal and ventral striatum for the varenicline group compared with placebo. Varenicline increases dopamine D2/3 receptor availability in drug-naïve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking.
Language
English
Source (journal)
Addiction biology. - Abingdon, 1996, currens
Publication
Abingdon : 2009
ISSN
1355-6215
Volume/pages
14:4(2009), p. 500-502
ISI
000269674600014
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 11.03.2014
Last edited 16.09.2017